Last Updated: 16/07/2025
Regulation and mechanism of Anopheles amino acid transport protein PATH on the ability of mosquito propagation of Plasmodium
Objectives
To further understand the mechanism of PATH in vector competence, this project will investigate:
- the influence of PATH on parasites protein anabolism,
- the influence of PATH of TOR, and
- the influence of PATH on innate immunity.
Rationale and Abstract
Malaria parasites must complete their lifecycle in mosquitoes by scavenging nutritions from host, but the metabolic interactions between vector and Plasmodium is unknown. Previous studies showed that amino acid transporter, path was induced 24 hr post parasite infection. It was mainly expressed in the epithelia of mosquito midgut. In the absence of PATH, mosquito become significantly susceptible to Plasmodium invasion, which indicates that PATH may promote the infection of parasites in mosquito. The final goal is set up knowledge base for developing transmission blocking vaccine.
Themes
Date
Jan 2017 — Dec 2019
Total Project Funding
$25,148
Funding Details
Project Site
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