Last Updated: 10/07/2025
Are rare sugars potential leads for malaria eradication?
Objectives
*Original title and text were machine translated from Japanese
This study was designed to evaluate in vitro effects of rare sugars on the parasite stages in the human blood stream and verify the hypothesis: Inhibition of glucose transport by the rare sugar killed the parasites in the mosquitoes.
One of rare sugars inhibits developments of malaria parasites in vector mosquitoes. Elucidation of the mechanism of the action is expected to support developments of malaria transmission blocking drugs. Addition of the rare sugars to the culture media of the intraerythrocytic and the sexual stages did not show any effects on the parasites. This suggests that the effect of the rare sugar on the parasite developments in the mosquitoes should not be caused by inhibition of glucose transport.
Apr 2017 — Mar 2019
$38,683
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