Last Updated: 29/10/2025
Long-acting antimalarials for malaria chemovaccination
Objectives
This project will determine why vaccination using drug-attenuated liver stage parasites may be a superior approach.
Principal Institution
Walter and Eliza Hall Institute of Medical Research (WEHI), Australia
Principal Investigators / Focal Persons
Rationale and Abstract
Sterile immunity to malaria is not developed naturally; rather, immunity involves tolerance to severe disease, which only develops after repeated infections but does not block reinfection. The most efficacious immunity so far identified in clinical trials is with controlled human infection using live sporozoites and chloroquine prophylaxis, which kills blood stage parasites.
External reference
Themes
Date
Jan 2025 — Dec 2028
Total Project Funding
$1.21M
Funding Details
National Health and Medical Research Council (NHMRC) Australia, Australia
Grant ID: 2036883
AUD 1.84M
Project Site
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