Last Updated: 20/03/2025
The molecular basis of rapid cellular replication in the malaria parasite
Objectives
This project will reveal the molecular mechanisms that malaria parasites use to rapidly replicate and divide within the cells of the people they infect, and the mosquitoes that transmit them.
Monash University (MON), Australia
University of Adelaide, Australia
Malaria is a major health burden in tropical regions, but our understanding of the parasite that causes this disease is limited. The malaria parasite lifecycle requires three stages of rapid replication, and new components of the parasite’s replication machinery have recently identified that are likely responsible for this unique process. This research will reveal how malaria parasites perform extremely rapid replication of their DNA. New molecular and proteomics technologies will be used, and integrate these with AI to reveal how proteins interact to facilitate rapid replication. The findings will underpin future research aimed at developing new interventions for malaria and related infections in wildlife, livestock and humans.
Jan 2025 — Dec 2027
$572,364
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