Last Updated: 14/03/2025
Individual variation in malaria risk: causes and consequences in Amazonian populations
Objectives
*Original title in Portuguese: Variação individual no risco de malária: causas e consequências em populações amazônicas
The goal of this project is to improve the existing models by integrating new evidence generated by project collaborators (in the areas of molecular biology, genetics, and entomology) to better describe the transmission dynamics of vivax malaria. The models aim to provide evidence for the definition of potential control measures to reduce the incidence of malaria in the Amazon Basin.
Numerous genetic and behavioral factors influence the risk of contracting malaria. Evidence suggests that certain naturally acquired antibodies are associated with a lower risk of clinical malaria in endemic areas. Conversely, some work activities are known to increase the risk of malaria. In this context, it is demonstrated that components of the transmission dynamics of vivax malaria in the Amazon can be described by simple mathematical models based on ordinary differential equations that take into account the heterogeneity of risk in the local population.
Aug 2024 — Jul 2026
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