Global Health EDCTP3 Work Programme 2025
The Global Health EDCTP3 Work Programme 2025 has been published and includes four calls for proposals, covering seven topics, with a total budget of €214 million. Here, you can find the ones related to malaria:
Malaria therapeutics and clinical development of new antimalarial candidates
Proposals submitted under this topic are expected to advance the clinical development of existing and new antimalarial candidates. The development of prophylactic vaccines and monoclonal antibodies is not in scope for this topic.
Proposals should carry out early and/or late-stage clinical studies to evaluate the safety, efficacy and effectiveness of new combinations of currently approved or novel therapeutic candidates targeting individuals in SSA. Proposals are to generate clinical data targeting children, pregnant women, and immune-compromised individuals or adolescents living in high transmission regions as relevant. Interventions may target both P. Falciparum and/ or P. Vivax. Promising transmission blocking agents may be included as part of combination therapies.
To this end, proposals submitted under this call topic should address at least two of the following, with the first being mandatory:
- Clinical trials from Phase 2a onwards, to progress the development of new combinations of currently approved or novel therapeutic candidates;
- Long term effectiveness studies through aligned primary endpoints where possible;
- Generation of pharmacovigilance data on currently registered therapeutics or candidates in late- stage efficacy trials;
- Evidence on resistance to current treatments including combined therapies as secondary outcome.
Strategic training hubs for fellowships in public health
The objective of this topic is to establish an African cohort of epidemiologists, biostatisticians, mathematical modellers by supporting institutions in SSA and Europe that provide Master’s training in epidemiology and biostatistics or those that process public health data with advanced quantitative methods to inform policy, as part of the Africa CDC’s framework for public health workforce development.
The Master’s degree courses with practical field research experience must be robust and of the level oftraining for the epidemiology and biostatistics that is delivered within reasonable time for the required numbers and high-quality fit-for purpose personnel urgently needed in zones of outbreak/epidemic risks in SSA. Early- to mid-career researchers or data scientists (or similar) are the targeted level of training for the infectious disease modelling.
Transformative innovations in global health
The objective of the topic is to progress a development which meet at least one of the below:
- Innovations in R&D or products implementation focusing on new or improvement of existing medicinal products and delivery systems of new or improved medical technologies within the health systems. This may include but not limited to use of new technologies;
- Development of a new intervention or improvements of an existing intervention for age-appropriate formulations or underserved populations. This may include but not limited to development of paediatric or geriatric formulations generating data for patients with co-morbidities;
- Development of tools to improve the affordability or accessibility of preventative/ treatment/ diagnostic solutions in SSA or specific vulnerable populations as relevant. This may include but not limited to development of thermostable or humid resistant formulations, lower cost of goods, dose sparing approaches;
- Accelerate the development of delivery systems which will improve the efficacy or uptake of the preventative/treatment/diagnostic solutions in SSA. This may include but not limited to assessing different route of administration ensuring easier access, new or improved devices or equipment ensuring higher efficacy or uptake, etc;
- Leverage existing data to repurpose and expand the use of the preventative/ treatment/ diagnostic intervention. This may include but not limited to using well-established safety and pharmacological data from its use in one disease area into the infectious disease field in the scope of the Global Health EDCTP3.
Scope includes infectious diseases in scope of the Global Health EDCTP3 including HIV/AIDS. Proposal sare to generate beyond proof-of-concept data.
More information, please read here.
Application deadline, 20th of March, 2025 at 17:00h CET.
