Last Updated: 11/11/2024
Genetic dissection of merozoite invasion by taeget gene analysis of merozoite-specific transcription factors in malaria parasites
Objectives
The main goal of this study is to identify novel genes involved in merozoite invasion and elucidate their gene expression mechanisms by analyzing the target genes of AP2M, the master transcription factor of merozoites, using the ChIP-seq method.
Erythrocyte invasion by merozoites of malaria parasites is a complex phenomenon consisting of steps such as escape from infected erythrocytes, adhesion to new erythrocytes, apical reorientation, invasion with parasitic spores, and post-invasion stage change. ChIP-seq analysis of human Plasmodium falciparum AP2M identified 503 target genes and its binding motif. It revealed that AP2M bind to the binding motifs in the upstream sequences of the target genes to activate their transcription.
Apr 2018 — Mar 2021
$40,673
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