Last Updated: 02/08/2024
Studying molecular mechanisms that maintain hierarchical phospholipid variety formed in Plasmodium falciparum-infected erythrocytes
Objectives
*Original title and text were machine translated from Japanese.
This study focused on how red blood cells infected with late red malaria maintain the optimal membrane lipid molecular composition, and conducted functional and cell biological analyzes of the acyltransferase group that forms the core of phospholipid variety.
P. falciparum malaria in the red blood stage invades red blood cells, grows from the red blood cell membrane into the parasitic vacuole membrane, and multiplies. As the protozoan matures within the cell, the host red blood cell membrane, the parasitophorous vesicle membrane surrounding the protozoan, and the lipid composition of the parasitic protozoan become three different molecular compositions. This difference is mainly determined by the combination of the phospholipids and the two acyl chains they contain, and there are thousands of different types of phospholipids. This diversity also affects the physical properties of each membrane, maintaining the overall balance of infected cells.
Apr 2023 — Mar 2026
$33,940
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