Malaria Genomic Epidemiology Journal Club: Insecticide resistance evolution
Malaria Genomic Epidemiology Network (MalariaGEN) is inviting registrations for the Malaria Genomic Epidemiology Journal Club on “Insecticide resistance evolution”.
Date: March 19, 2024
Time: 1:30pm GMT
Speaker
- Sanjay Nagi, is a post-doctoral fellow studying genomics of the major malaria mosquito, Anopheles gambiae, at the Liverpool School of Tropical Medicine. In a new pre-print (https://academic.oup.com/jid/advance-article/doi/10.1093/infdis/jiad522/7441649?login=true), Nagi and colleagues used a population genomic approach to identify novel mechanisms of resistance to pirimiphos-methyl, an organophosphate insecticide widely used in indoor residual spray campaigns. They discovered ongoing parallel evolution between An. gambiae s.l and the common house mosquito, Culex pipiens, and found that a gene amplification in An. gambiae in West Africa is associated with resistance to pirimiphos-methyl. Overall, they demonstrate a striking example of parallel evolution which has important implications for malaria control programmes.
To register click here.
