Last Updated: 09/02/2026

Genomics of African Vectors for NMCP Management of Insecticide Resistance

Objectives

To provide training and support to conduct genomics studies on African malaria vectors.

Principal Institution

Kenya Medical Research Institute (KEMRI), Kenya

Principal Investigators / Focal Persons

Rationale and Abstract

Indoor residual spraying (IRS) and insecticide-treated nets (ITNs) are the main methods used to control mosquito populations for malaria prevention. The efficacy of these strategies is threatened by the spread of insecticide resistance (IR), limiting the success of malaria control. Studies of the genetic evolution leading to insecticide resistance could enable the identification of molecular markers that can be used for IR surveillance and an improved understanding of the molecular mechanisms associated with IR.

Study Design

This study used a weighted gene co-expression network analysis (WGCNA) algorithm, a systems biology approach, to identify genes with similar co-expression patterns (modules) and hub genes that are potential molecular markers for insecticide resistance surveillance.

Project Outputs

Article: Key gene modules and hub genes associated with pyrethroid and organophosphate resistance in Anopheles mosquitoes: a systems biology approach Article: Genomic diversity of the African malaria vector Anopheles funestus Article: Molecular surveillance leads to the first detection of Anopheles stephensi in Kenya Article: Spatial distribution, genetic analysis, and population structure of the invasive Anopheles stephensi in Kenya: 2022-2024

External reference

Project details

Themes

Capacity Strengthening
Enabling Technologies & Assays
Health Systems
Vector Control

Date

Nov 2021 — May 2024

Total Project Funding

$709,988

Funding Details

Gates Foundation (GF), United States