Last Updated: 22/02/2024
Population genomics and evolutionary history of mosquitoes-vectors of human diseases in Russia
Objectives
This project is aimed to better understand the population structure and evolutionary history of six most dangerous vectors of human infectious diseases in Russia: Anopheles messeae, An. daciae, that can transmit malaria parasite; Culex pipiens pipiens, Cx. p. molestus, involved in transmission of West Nile virus; as well as Aedes aegypti and Ae. albopictus which are responsible for the transmission of dengue and Zika viruses. This project will also determine the diversity in the mosquito populations and the patterns of their migration.
Institute of Cytology and Genetics of SB RAS, Russian Federation
Mosquitoes are known not only because of their annoying buzzing and irritated bites, but more importantly because, during blood-feeding female mosquito could transmit pathogens that cause devastating diseases such as malaria, dengue, viral fevers and filariasis. Despite the fact that entomological and genetic studies of these mosquitoes were conducted in the past, these species have never been investigated from the perspectives of genomics. This project will employ the most advance genome technologies and tools that are currently available such as whole-genome Illumina sequencing, Hi-C, as well as molecular cytogenetics on both polytene and mitotic chromosomes. This study will help to better understand the species composition, their origin, and current distribution in different regions of Russia. This knowledge about diversity of mosquito population is extremely important for predicting further propagation of these mosquitoes and the diseases that they could transmit in Russia. It is envisioned that this study will stimulate further development of mosquito genomics in Russia aimed at designing adequate and accurate strategies for the disease control.
Jan 2019 — Dec 2021
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