Biomarkers, immune response and mechanisms associated with protection or morbidity in protozoan infections: Leishmania, Plasmodium, Trypanosoma cruzi and Toxoplasma gondii

Objectives

This is an “umbrella” project that houses sub-projects with the objectives of:

1. Identify morbidity biomarkers in malaria caused by Plasmodium vivax: inflammatory mediators and miRNA;
2. Study the immune response and mechanisms associated with protection and morbidity in Plasmodium infections in populations exposed to malaria;
3. Identify and carry out the immunological characterization of B and T cell epitopes in Plasmodium sp. and its implications in vaccine processes;
4. Identify modulators in the immune response in Chagas disease and Leishmaniasis;
5. Study the role of CD4-CD8- T cells in Chagas disease
6. Study of the role of extracellular networks of T lymphocytes (LETs) and “tissue resident macrophages” in leishmaniasis;
7. Study the immune response in toxoplasmosis.