Last Updated: 18/06/2024
Translational Control In Plasmodiuim falciparum
Objectives
The aim of this project is to conduct a comprehensive investigation on the systemic regulation of translation during stress responses in the parasite P. falciparum.
Specific objectives are;
1) to characterize a novel and universally conserved ribosome associated factor in P.falciparum and its role in stress responses.
2) to provide supporting evidence for the presence of functionally specialized ribosomes.
3) to identify common stress response pathways through studying the tRNA epitranscriptome.
4) to develop a high-throughput drug screening assay
Plasmodium falciparum is a parasite that causes human malaria which remains one of the most important infectious diseases worldwide. Managing this global emergency will require a deeper understanding of the resistance mechanisms developed by the parasite to survive in the presence of artemisnins, as well as opening up new therapeutic avenues. As of recently, mounting evidence converges to suggest a strong tie between the phenotypic characteristics of artemisinin resistance to general cellular stress response mechanisms. The reserachers will approach the aim of this project by first establishing a deeper understanding of the ribosome and the transfer ribonucleic acid (tRNA) biology in the parasite with the use of various molecular assays and subsequently decipher how the regulation of two abundant non-coding ribonucleic acid (ncRNA) classes may affect the translatome and the functional proteome output during stress conditions.
Jan 2022 — Dec 2025
$795,542
Related Resources
