Last Updated: 16/05/2023
The role of host cell proteins in survival and propagation of the human malaria parasite P. falciparum
Objectives
To understand the modification mediated by a number of parasite-encoded proteins that are transported to the host cell.
The malaria parasite P. falciparum modifies its chosen host cell, the mature human erythrocyte. This modification is mediated by a number of parasite-encoded proteins that are transported to the host cell. It is however not clear how these proteins are transported to the host cell. This project aims to understand this process. The hypothesis is that human proteins are recruited by the parasite to aid in transport of its own proteins to the host erythrocyte. Using a variety of methods, we aim to study the role of human chaperones in this process. Potential new mechanisms which we uncover may provide a potential achilles heel for development of anti-parasite therapies.
Article: Co-chaperone involvement in knob biogenesis implicates host-derived chaperones in malaria virulenceFinal Report
Jan 2017 — Dec 2021
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