Last Updated: 23/03/2023
Molecular basis of artemisinin action and resistance in Plasmodium falciparum
Objectives
To identify the components of the parasite’s cellular defence system that underpin resistance and will point to strategies for overcoming resistance to this important drug class.
Principal Institution
Principal Investigators / Focal Persons
Rationale and Abstract
The malaria parasite, P. falciparum causes ~450,000 deaths each year. Resistance to the front-line antimalarial drug, artemisinin, is increasing, threatening at least another 100,000 lives per year, and potentially causing an additional ~A$500M in lost productivity. This project will identify the components of the parasite’s cellular defence system that underpin resistance and will point to strategies for overcoming resistance to this important drug class.
External reference
Themes
Date
Jan 2018 — Dec 2021
Total Project Funding
$546,148
Funding Details
National Health and Medical Research Council (NHMRC) Australia, Australia
Grant number: 1139884
Project Site
Related Resources
