Last Updated: 01/12/2025
Anopheline anti-platelet protein, AAPP, regulates probing time and blood feeding success in the malaria vector mosquito, Anopheles stephensi
Objectives
To develop a new concept malaria vaccine based on the hypothesis that;
- allergens containing saliva components disrupt and/or weaken host immune system;
- functional domains of saliva proteins are hidden from host immune attack, resulting in induction of antibodies to non-functional domains of those proteins.
Principal Institution
Principal Investigators / Focal Persons
Rationale and Abstract
People living in a malaria endemic area cannot induce either protective immunity against malaria infection or inhibitory immunity against mosquito behavior following mosquito blood feeding. We hypothesize that (1) allergens containing saliva components disrupt and/or weaken host immune system, (2) functional domains of saliva proteins are hidden from host immune attack, resulting in induction of antibodies to non-functional domains of those proteins. The vaccine consisting of mosquito saliva proteins will overcome those allergy and decoy.
External reference
Themes
Date
Apr 2015 — Mar 2017
Total Project Funding
$32,000
Funding Details
Project Site
Deep Dives
Related Resources
