P. Falciparum Infection Dynamics and Transmission to Inform Elimination (INDIE-1b)

Objectives

In the current study, the investigators will first improve access to care in all villages by implementing community-based clinical case management (CCM) (year 1). During the second year, the study will directly evaluate the effect of CCM on the human reservoir of infection as compared to three different experimental approaches aimed at reducing malaria transmission, namely: (i) Active fever screening and treatment that should detect symptomatic infections for early treatment; (ii) Mass Screening and Treatment (MSAT) that will systematically screen the whole population using point-of-care diagnostics, with infected individuals immediately treated; and (iii) Mass drug administration (MDA) that will treat the whole population with a full course of an antimalarial treatment.