Last Updated: 10/12/2019
Disc-shaped point-of-care platform for infectious disease diagnosis (DiscoGnosis)
Objectives
The project aims to develop a fully-automated, user-friendly diagnostic platform, based on integration/convergence of micro, nano, biotechnologies at low production cost, for quick, reliable, accurate, cost-efficient diagnosis at the point-of-need.
This objective will be achieved through:
- Multi-pathogen detection: parasites, viruses, bacteria
- Combined detection of protein and DNA
- Full integration in a centrifugal microfluidic platform (LabDisk cartridge and portable device)
- Scalable, polymer foil-based production technology
- Isothermal real-time amplification
- Point-of-care platform
- Quality control
- Demonstration in Africa with clinical samples
University Hospital Basel, Switzerland
Rohrer AG, Germany
University Medical Cente Göttingen(UMG), Germany
University of Stirling (UoS), United Kingdom
Magnamedics Diagnostics BV, The Netherlands
European Foundation for Clinical Nanomedicine (CLINAM), Switzerland
Mast Group Ltd. (MAST), United Kingdom
Malaria is one of the most crucial health threats. An estimated 220 million people get infected every year; 650.000 cases lead to death, 20% of which are within small children. The disease is still on advance mainly in Africa and other tropical developing countries with acute fever being the only symptom. In these regions, fever can also result from Salmonella Typhi/Paratyphi bacteria or dengue and chikungunya viruses, all of which, like malaria, are transmitted by mosquitos. Clinical surveys have shown that 30 to 40% of the patients are falsely treated for malaria without even being infected by it, due to inaccurate diagnosis. It is, therefore, vital to establish accurate diagnostic tools to distinguish these diseases and apply the appropriate therapy.
Nov 2012 — Apr 2016
$4.95M
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