Last Updated: 27/06/2024
G4P: Scaling up fetal Growth 4 Peanuts
Objectives
This project aims to improve fetal growth through dietary supplementation of L-arginine, an amino acid essential for placental development that is reduced in malaria.
Globally 60% of pregnant women are at risk of malaria infection in pregnancy, placing the lives of both the mother and fetus at risk. In sub-Saharan Africa, an estimated 25% of all pregnancies show signs of malaria infection in the placenta at delivery. During pregnancy, malaria-infected red blood cells preferentially accumulate in the placenta, resulting in maternal anemia, miscarriage, poor fetal growth, preterm birth and stillbirth. A central component of antenatal care in malaria-endemic regions is the administration of a single dose of safe, effective and long-lasting antimalarial drug at each antenatal visit, starting mid-pregnancy. However, the emergence of widespread resistance against antimalarial drugs currently used and a lack of safe alternatives threaten the success of these programs.


