Last Updated: 30/06/2024
Heat shock drugs for malaria: reversing resistance
Objectives
This project seeks to circumvent drug resistance by targeting a molecular chaperone called Heat Shock Protein 90, the master regulator of the parasite stress response.
Principal Institution
Principal Investigators / Focal Persons
Partner Institutions
Rationale and Abstract
Malaria is one of the biggest infectious killers globally and drug resistance is a major reason why. Close to 600,000 people die from malaria infection annually, with Sub-Saharan Africa suffering the brunt of the mortality. A contributing factor is the emergence of antimalarial resistance to the best drugs available, including artemisinin and its partner drugs, such as piperaquine.
External reference
Date
Apr 2013 — Sep 2014
Funding Details
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