Last Updated: 13/11/2025
Intermittent preventive treatment in children combined with malaria home management in an area with persisting high malaria prevalence in Senegal
Objectives
To determine whether seasonal IPTc with sulfadoxine-pyrimethamine plus amodiaquine provides added benefit in populations with access to prompt effective treatment through home–based management; whether IPTc has previously been shown effective when given for three months in areas with a short transmission season and whether seasonal IPTc is safe and acceptable when given for a longer period in areas with a longer transmission season. To also show the cost-effectiveness of adding seasonal IPTc to home management of malaria (HMM).
Malaria is a major public health problem. 250 million cases annually leads to approximately 1 million deaths. Over 80 per cent of these deaths occur among African children under age five. The main interventions covered treatment with Artemisinin Combination Therapies (ACT), long lasting bednets distribution and Rapid Diagnosis Tests (RDT) to improve malaria diagnosis.
This has led in Senegal to a substantial decrease in the incidence of malaria, in 2009. However, the recent overall decline hides the fact that malaria incidence remains very high in the south of Senegal. That’s why Home-based management (HMM) for malaria is being introduced in selected areas. Intermittent Preventive Treatment (IPT) by monthly administration of a therapeutic dose of antimalarials can achieve a very high degree of protection from attacks of clinical malaria in children. The purpose of this project is to evaluate the effectiveness of combining IPTc with HMM in southern Senegal.
ClinicalTrials.gov Identifier: NCT01449045
| Study Type : | Interventional (Clinical Trial) |
| Allocation: | Randomized |
| Intervention Model: | Parallel Assignment |
| Masking: | None (Open Label) |
| Primary Purpose: | Prevention |
Article: Seasonal malaria chemoprevention combined with community case management of malaria in children under 10 years of age, over 5 months, in south-east SenegalArticle: Large-scale delivery of seasonal malaria chemoprevention to children under 10 in Senegal: an economic analysisArticle: Effectiveness of Seasonal Malaria Chemoprevention in Children under Ten Years of Age in Senegal: A Stepped-Wedge Cluster-Randomised TrialArticle: Safety of Seasonal Malaria Chemoprevention (SMC) with Sulfadoxine-Pyrimethamine plus Amodiaquine when Delivered to Children under 10 Years of Age by District Health Services in Senegal: Results from a Stepped-Wedge Cluster Randomized Trial
Apr 2011 — Apr 2013
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