Last Updated: 29/06/2026
Export of PfEMP1, the major virulence protein of P. falciparum, to the parasite infected erythrocyte surface
Objectives
The malaria parasite infects red blood cells in the human host and initiates major remodelling. This involves export of a major virulence protein to the surface of the red blood cell. This research seeks to understand how the parasite exports this protein, a key determinant of disease.
Principal Institution
Walter and Eliza Hall Institute of Medical Research (WEHI), Australia
Principal Investigators / Focal Persons
Partner Investigators
Project Outputs
- Article: Plasmepsin X activates the PCRCR complex of Plasmodium falciparum by processing PfRh5 for erythrocyte invasion - [Nat Commun, 2023]
- Article: RH5.1-CyRPA-Ripr antigen combination vaccine shows little improvement over RH5.1 in a preclinical setting - [Front Cell Infect Microbiol, 2022]
- Article: Neutralising antibodies block the function of Rh5/Ripr/CyRPA complex during invasion of Plasmodium falciparum into human erythrocytes - [Cellular Microbiology, 2019]
- Article: Export of virulence proteins by malaria-infected erythrocytes involves remodeling of host actin cytoskeleton - [Blood, 2014]
- Article: Vaccination with Conserved Regions of Erythrocyte-Binding Antigens Induces Neutralizing Antibodies against Multiple Strains of Plasmodium falciparum - [PLoS One, 2013]
External reference
Themes
Date
Jan 2011 — Dec 2013
Total Project Funding
$594,837
Funding Details
National Health and Medical Research Council (NHMRC) Australia, Australia
Grant ID: 1011453
AUD 588,532
Country / Project Site(s)
Related Resources
