Last Updated: 09/10/2019

Delivery of Malaria Chemoprevention in the Post-discharge Management of Children With Severe Anaemia in Malawi (PMC)


The overall goal of this project is to design and evaluate an effective delivery mechanism for post-discharge malaria chemoprevention (PMC) within the health system.

The primary objective is to determine the optimum PMC delivery mechanism by comparing community- versus health facility-based strategies in order to inform policy.

Principal Investigators / Focal Persons

Kamija Phiri

Rationale and Abstract

In malaria-endemic countries of sub-Saharan Africa, many children develop severe anaemia due to previous and current malaria infections. After blood transfusions and antimalarial treatment at the hospital, they are usually discharged without any follow-up. In the post-discharge period, these children may contract new malaria infections and develop rebound severe anaemia. Identifier: NCT02721420

Study Design
Study Type  : Interventional  (Clinical Trial)
Estimated Enrollment  : 375 participants
Allocation: Randomized
Intervention Model: Factorial Assignment
Masking: None (Open Label)
Primary Purpose: Prevention

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