Last Updated: 16/06/2015

Studies of a Candidate Aminoquinoline Antimalarial (AQ-13)

Objectives

Principal Institution

Tulane University

Principal Investigators / Focal Persons

Donald Krogstad

Partner Institutions

University of Bamako

Rationale and Abstract

This is an initial efficacy study of a candidate antimalarial in human subjects with uncomplicated malaria caused by the most common and most important parasite in Africa (Plasmodium falciparum). This study will enroll 66 adult Malian males with uncomplicated P. falciparum malaria and randomize them to treatment with 1750 mg of the investigational drug (AQ-13) by mouth over 3 days or the current standard treatment, which is 4 tablets of Coartem twice daily for 3 days. The hypothesis underlying this study is that AQ-13 will be similarly effective to Coartem for the treatment of uncomplicated P. falciparum malaria due to both chloroquine-susceptible and chloroquine-resistant parasites

Date

Aug 2013 — Jun 2016

Project Site

Africa, Western
Mali

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