Last Updated

24 Jul 2018

Reactive case detection with targeted mass drug administration: Interrupting malaria transmission and achieving elimination beyond intervention areas in northwestern Peru


Main objective: To assess the effect of RCD/tMDA on malaria incidence in intervention areas of Peru

Specific objective: To estimate the effectiveness of Reactive Case Detection (RCD) with Focal Mass Drug Administration (fMDA) as compared to passive case detection (PCD) in reducing the incidence of malaria to zero in Tumbes, Peru

Rationale and Abstract

The pilot study was implemented in 2009-2010 and then it was scaled up to 13 districts in 2011-2015.

Study design: 

  • Type: Community trial
  • Allocation: Non- randomized
  • Intervention model: Parallel
  • Masking: None (open label)
  • Primary purpose: To assess effectiveness

Drug and regimen: Chloroquine over 72 hr (25mg/kg) + primaquine for 7 days (0.5mg/kg) through Directly-Observed Therapy (DOT)

Outcome measure: Annual parasite incidence by microscopy

*Check what the researchers presented at ASTMH 2017 in the Knowledge Hub