Last Updated: 16/02/2024

Plasmodium knowlesi as a genetic model for Plasmodium vivax drug resistance

Objectives

To use a closely related parasite, P. knowlesi, as a model to understand drug resistance mechanisms of P. vivax.

Principal Investigators / Focal Persons

Brendan Elsworth

Rationale and Abstract

Two different Plasmodium parasites cause the majority of malaria worldwide. However, one type, P. vivax, is unable to be cultured in the laboratory and therefore has been poorly studied. Drug resistance has been observed but the underlying causes are poorly understood. This proposal sets to use a closely related parasite, P. knowlesi, as a model to understand drug resistance mechanisms. This knowledge will be used to follow resistance in the field and direct policy of the most appropriate treatment.

Thematic Categories

Drug Resistance
P. vivax

Date

Jan 2018 — Dec 2021

Total Project Funding

$294,337

Project Site

Australia

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