Last Updated: 04/03/2024

Plasmodium biosensor based on trimodal interferometry

Objectives

*Original title in Portuguese: Biossensor plasmônico baseado em interferometria trimodal

This proposal involves activities of technological research, and has as objective the development of compact bioactive nanofotonic systems based on plasmodial trimodal interferometers.

Principal Investigators / Focal Persons

Hugo Enrique Hernandez Figueroa

Rationale and Abstract

The extremely high product sensitivity of the extensive evanescent field of the trimodal devices will be even greater by the plasmons generated in our system. The combination of the previously described concept with mass production technologies to define fluid manipulation (Direct Writing Laser – H-Line lithography) will be the basis of a fundamental technology with future applications ranging from food safety to medical- clinical. This new concept can be achieved by taking advantage of the extraordinary properties of the DWL writing system, capable of manufacturing well-defined structures with gauge resolution. The combination of the technologies detailed in this summary offers the following advantages: In the trimodal plasmid biosensor the increase in interaction length and in the evanescent field (EF) is drastic, providing a reduction of the detection limit (LOD) at least 100 times 1000), compared to conventional techniques reported in the literature. The device will be suitable for detecting metabolites secreted from the bacterium Klebsiella pneumoniae, and thus be able not only to detect the presence of bacteria but more importantly to determine their status. This will open the door to measuring antimicrobial resistance and the minimum inhibitory concentration of specific drugs. The time to get product results of the analysis done on our device will be a few minutes and you will not need to wait long hours for a reliable result. The specificity will be guaranteed in our device through the biofunctionalisation made in the proposed component, based on specific antibodies created using the hapten PC1, thus minimizing the number of false / negative positives. The proposed device is based on research work conducted by the research group led by the proposer [1-6], and is based on the use of polymeric photonic guides and plasmid structures in order to guarantee manufacturing flexibility, reliability, low energy consumption and potential of mass production with reduced manufacturing costs.

Thematic Categories

Diagnostics
Product Development

Date

Feb 2019 — Feb 2022

Project Site

Brazil

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