Last Updated: 19/06/2024

The importance of malaria in the hygiene hypothesis: the suppressive effects of Plasmodium infection against immune disorders


*Original title and abstract were machine translated from Japanese.

This study will experimentally verify the significance of malaria in the hygiene hypothesis and elucidate its mechanism by analyzing the effects of malaria infection on animal models of autoimmune diseases and allergic diseases.

Principal Investigators / Focal Persons

Shoichi Shimizu

Rationale and Abstract

An increase in autoimmune and allergic diseases has been reported in developed countries with improved hygiene, and the reason is that “in the unsanitary environment of developing countries, moderate exposure to pathogens keeps the immune system normal. However, in developed countries, the “hygiene hypothesis” is known that “immune diseases are increasing due to the loss of it.” Malaria is one of the most common and most important infectious diseases in tropical developing countries, but its relevance to this hypothesis is completely unknown. 

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Apr 2022 — Mar 2025

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