Last Updated: 01/03/2024

Effect of vivax malaria on drug metabolism and the influence of cyp2d6 and cyp2c8 genotypes on response to antimalarials

Objectives

*Original title in Portuguese: Efeito da malária vivax na metabolização de medicamentos e a influência de genótipos de cyp2d6 e cyp2c8 na resposta aos antimaláricos

This is an observational cohort study, which seeks to identify the influence of polymorphisms in the CYP2D6 and CYP2C8 gene on chloroquine metabolism in patients with reported chloroquine resistance. Thus, from the understanding of the genotype of the patients, it will be possible to relate the influence of the enzymatic activity of CY2P2D6 with the clinical response to the treatment.

Principal Institution

Oswaldo Cruz Foundation (Fiocruz)

Principal Investigators / Focal Persons

Wuelton Marcelo Monteiro

Date

Apr 2019

Funding Details
Project Site

Brazil

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