Last Updated

23 Nov 2018

A comparison of reactive case detection strategies in the Central Highlands areas of Madagascar to inform the national malaria control strategy toward elimination


The primary objective of this OR study is to compare the feasibility and effectiveness of two different reactive case detection approaches in the Central Highlands of Madagascar for reducing malaria transmission, measured by the number of additional cases detected and by reductions in transmission over time using PCR and serology.

Secondary objectives include:

  • Evaluate and compare the costs of two approaches to reactive case detection
  • Determine the numbers of additional cases detected and any further reductions in transmission by expanding the screening radius around the index case
  • Assess the effectiveness of mobile technology to enhance active surveillance
  • Determine the proportion of malaria infections that would be missed by screening with rapid diagnostic tests (RDTs) as opposed to more sensitive diagnostic tools such as PCR, LAMP and highly-sensitive RDTs.
Rationale and Abstract

This study has been cancelled.

The type of intervention tested is focal screening with RDT or focal mass drug administration around passively detected index malaria cases. 195000 individuals from 39 clusters in the 14 Central Highlands Districts in Madagascar will be included in the study. 

Study Design

Cluster randomized trial with two intervention arms and one control arm.

Thematic Categories


2016 Apr - 2019 Jun

Total Project Funding

Project Site