Clinical development of Pfs48/45 as transmission blocking vaccine
Pfs48/45 is the most advanced EU-developed malaria TB vaccine candidate. PF10C is a subunit of Pfs48/45 that has been produced as R0-PF10C. Immunization with 100% properly folded R0-PF10C induced transmission-blocking activity in 100% of immunized mice.
The objectives of REDMAL are:
1. Manufacture R0-PF10C at cGMP grade
2. Prepare for clinical trials with R0-PF10C in Africa.