Last Updated: 05/08/2015
Biomarkers for Malaria Elimination (BIOME)
Objectives
Biomarkers for Malaria Elimination (BIOME) will generate clinical data to better understand the concentration of key Plasmodium falciparum biomarkers—including histidine-rich protein 2, parasites, and nucleic acids—and their kinetics over the course of an infection. The results will provide a clearer understanding of the potential of new highly-sensitive tests for detecting infected individuals with low-density infections.
University of California San Francisco (UCSF), United States
PATH, United States
PATH is conducting research into biomarkers for Plasmodium falciparum and Plasmodium vivax infections to guide development of new diagnostics. Using clinical samples collected from asymptomatic individuals, PATH measured HRP-II, lactate dehydrogenase (LDH), and parasite nucleic acids throughout the course of Plasmodium falciparum infection and applied this information to measure the sensitivity of various tests commercially available and in development.
May 2015 — Apr 2016
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