Last Updated

08 Apr 2021

P. falciparum infection dynamics and transmission to inform elimination (INDIE)

Objectives

This multicenter study aims to measure the duration of carriage of asymptomatic P. vivax and P. falciparum infections in a low endemic setting in Ethiopia and other areas.

This project includes four specific aims: 

  1. To quantify the fluctuation in parasitemia
  2. To assess the association between  gametocytes and asexual parasite densities
  3. To evaluate the duration of infectiousness 
  4. To measure anti-gametocyte antibodies  
Principal Investigator
Rationale and Abstract

Most of the published studies on the infectious reservoir for malaria  were based on cross-sectional studies and thus not able to capture details on the natural history of these infections. No study, to date, has formally evaluated the dynamics of the low-density  infections in relation to their infectivity to mosquitoes and the factors that govern infection duration and gametocyte production. In this study, we aimed to precisely quantify the fluctuation association and their infectivity to mosquitoes in a sympatric low endemic setting for P. vivax and P. falciparum in Ethiopia and in other areas.

Study Design

Assessments of human infectivity to mosquitoes (mosquitoes were allowed to feed on human blood through membranes and the mosquitoes were later assessed for the presence of parasites).

  • Outcome measures: (Individual level) Detectability of infections by hsRDT in relation to HRP2 concentration, duration of infection, parasite density
  • Comparator: PCR
  • Population sample size: +1000

Date

2017 Aug - 2022 Jul

Total Project Funding

$7,241,620

Funding Details