Updates

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New publications from WHO GMP

Safety review of 8-aminoquinoline antimalarial medicines

Written by external authors, this document reviews published and unpublished studies about the safety of primaquine and its precursors, with particular attention to haemolytic anaemia in G6PD-deficient individuals. The study was prepared for and discussed at a 2012 meeting of the WHO evidence review group on the safety and effectiveness of single-dose primaquine as a P. falciparum gametocytocide.

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Publication: Planning meeting for operational research on malaria elimination. WHO Meeting report May 2014

WHO/GMP organized a planning meeting for operational research on malaria elimination on 17–18 October 2013 in Geneva, Switzerland.

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Review of 'what works' in elimination advocacy

Malaria Journal publishes an Open Access timely review of 'what works' in elimination advocacy. The authors identify 7 key advocacy elements for disease elimination:

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YouTube film Science to accelerate us to malaria eradication

A great new science lecture is available on the MESA YouTube channel: 'Science to accelerate us to malaria eradication', presented by Lee Hall at the Keystone Symposium 2014.

Lee presents some key concepts on the vibrant biomedical R&D agenda which we need to support progress towards global malaria eradication. In his lecture, he poses the question of how the changing epidemiology of malaria impacts on research and interventions and highlights five challenges:

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Feasibility and potential impact of screening for asymptomatic malaria in Cambodia

Cambodia is moving towards eliminating malaria. According to the WHO World Malaria Report, less than 100 deaths were attributable to malaria in 2012 (World Malaria Report 2013).

Data from the Cambodia Malaria Surveys of 2004, 2007 and 2010 show that clustering of malaria cases tends to happen not only at village but also at household level. The current research project tests the hypothesis that in a household where a febrile case is reported, testing and treating the co-habitants for asymptomatic malaria may help reduce transmission, and therefore support malaria elimination.

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Webinar 'Evaluating antimalarial safety' from ACT consortium, Oct 7th 2014

Clinical trials are not suitable to identify rare, potentially serious adverse effects of drugs, or to define their safety in high risk populations.

Artemisinin-based combination therapies (or ACTs) are considered safe, but there are concerns over their potential to cause damage to parts of the brain. There is also a concern about their safety in patients infected with HIV.

Collating safety data is a challenge in Africa, where most antimalarials are used and more vulnerable populations reside.

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MMV Announces Call for Applications for Malaria Box Challenge Grants

Grants will support researchers in following up on Malaria Box open source data, available on ChEMBL.

This call for applications is to encourage animal model testing of the Malaria Box hit compounds and their derivatives in neglected infectious disease models, such as schistosomiasis, cryptosporidiosis, filariasis, tuberculosis, as well as other infections where there is comorbidity in children with malaria.

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Malaria Eradication Scientific Alliance

MESA (the Malaria Eradication Scientific Alliance) follows-up on the malERA agenda and provides a dedicated platform for the community in order to accelerate the translation of the science of malaria eradication for impact.

With the community, MESA monitors progress and takes the next steps to advance the science of malaria eradication. MESA reviews existing evidence and supports projects on research questions critical to malaria eradication.

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GMAP2 online consultation launched late in 2014

The Second Global Malaria Action Plan (GMAP2) will cover the timeframe 2016-2025. You are strongly encouraged to have a look and contribute by sharing your vision for a malaria-free world. 

The GMAP2 will provide a global framework for action around which partners can coordinate their efforts to control and eliminate malaria. It is being developed to guide the financing and implementation of the Global Technical Strategy.  Go here for further information

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New Meeting Report: Operational Research on Malaria Elimination

The World Health Organization (WHO) has published the report of the planning meeting for operational research on malaria elimination held on 17–18 October 2013 in Geneva, Switzerland. This meeting is part of WHO's work on accelerating countries' transition from malaria control to malaria elimination which is supported by the Bill & Melinda Gates Foundation.