Laboratory research on ivermectin against malaria transmission
The overall goal of this project is to determine the suitability of ivermectin mass drug administration for malaria transmission control in Southeast Asia and Latin America, laboratory investigations were performed to determine ivermectin susceptibility, sporontocidal effect and inhibition of time to re-feed for the primary Amazonian malaria vector, Anopheles darlingi.
Novel vector control methods that can directly target outdoor malaria transmission are urgently needed in the Greater Mekong Subregion (GMS) to accelerate malaria elimination and artemisinin resistance containment efforts. Ivermectin mass drug administration to humans has been shown to effectively kill wild Anopheles and suppress malaria transmission in West Africa. Preliminary laboratory investigations were performed to determine ivermectin susceptibility and sporontocidal effect in GMS Anopheles malaria vectors coupled with pharmacokinetic models of ivermectin at escalating doses.
Methodology: To assess ivermectin susceptibility, various concentrations of ivermectin were mixed in human blood and fed to An. darlingi.
Primary outcomes measured:
- Mosquito survival
- LC50, LC25, LC5
- Sporontocidal effect