The Epidemiology of Malaria Control Strategies (Mali ICEMR Sub Project 1)
The goal of this project is to understand why different patterns of malaria epidemiology and endemicity are resilient to current control strategies at four sites in Mali. The four field sites exhibit different endemicities, length of seasonality, and different combinations of control interventions and duration of implementation of those interventions.
The specific aims are:
- Determine a cohort-based long-term effect of concurrent malaria control interventions on the incidence of uncomplicated and severe malaria in relation with asexual and sexual malaria infections at 4 ecological settings with a different combination of malaria control interventions in West Africa;
- Determine seasonal changes in malaria vector population composition, biting behaviour and sporozoite rates in relation to ongoing vector control tools deployed on each ecological setting;
- Assess the relationships between temporal and spatial variations in vector epidemiological parameters, and P. falciparum infection and disease in human populations.
Wide deployment of malaria control tools in the past decade, has significantly contributed to a substantial reduction of the incidence and deaths related to the disease in Sub-sahara Africa (ref). Yet, the region continues to carry a disproportionately high share of the global malaria burden of malaria deaths. Moreover, incidence remains high but stable in some settings while rebounding in others after a long period of decrease associated with the intensive deployment of malaria control tools.