Last Updated

24 Jan 2019

Endectocide use in livestock as a tool to help eliminate malaria in Central America


Targeted use of endectocides (such as ivermectin) in peridomestic livestock can significantly reduce the survival and longevity of zoophagic Anopheles vectors that feed on treated cattle. Because zoophagic vectors are responsible for much of the malaria transmission in Central America, malaria transmission will be reduced in areas where endectocides are given to livestock.

This proposal will determine if endectocides, when administered to cattle, reduce the survival and fecundity of zoophagic malaria vectors in Central America.

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Rationale and Abstract

Malaria is a major health problem throughout the tropical world and is transmitted by a variety of Anopheles mosquitoes. Core vector control interventions consist of indoor residual spraying of insecticides and long-lasting insecticidal nets. These are logical strategies in areas where the primary vector species feed at night on people sleeping in their houses and where mosquitoes rest inside the house after blood-feeding. But in Central America, much of the malaria transmission is due to malaria vectors that are exophagic (i.e., prefer to bite outdoors), exophilic (i.e., prefer to remain outdoors), and zoophagic (i.e., as likely to feed on non-humans as humans). To control mosquitoes with these behavioural characteristics requires a different approach. This proposal addresses the control of zoophagic vectors. Endectocides are chemicals that are widely used in the livestock industry to control parasites such as intestinal nematodes, ticks, mange mites, lice, and cattle grub. When ingested by mosquitoes in a blood meal, endectocides have also been shown to reduce the survival and fecundity of Anopheles malaria vectors. Use of endectocides in peridomestic livestock may simultaneously hasten malaria eradication, control ticks, and boost feed-conversion for livestock in Central America. 


2017 Jan - 2019 Dec

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