Effectiveness of Seasonal Malaria Chemoprevention in Koulikoro, Mali
The overall goal is to improve the effectiveness of Seasonal Malaria Chemoprevention (SMC) and reduce the burden of malaria in Mali. We will evaluate the effectiveness of three different treatment regimens for SMC with respect to implementation, malaria morbidity, cost, protective immunity to malaria and potential emergence of drug resistance with respect to implementation.
The objectives of this project are:
- To determine the effectiveness of SMC extended to children up to 10 years old on the incidence and prevalence of malaria over entire district of Koulikoro using a cluster randomized controlled trial study design
- To assess potential long term effect of SMC on malaria epidemiology (acquisition of protective immunity, parasite population dynamics, drug resistance and transmission)
- To conduct a cost-effectiveness analysis of SMC extended to 5-10 years old as compared with standard protocol of SMC provision to children less than 5 years old with regard to delivery and implementation strategies and financial cost per malaria case averted and per child
The findings from years 1 and 2 implementation studies will serve as the go (conduct high quality efficacy study) versus no-go (conduct further intervention effectiveness studies around operations and implementation strategies) criteria for years 3-5.
ClinicalTrials.gov Identifier: NCT04149106
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||4556 participants|
|Intervention Model:||Crossover Assignment|
|Intervention Model Description:||
A cluster randomized design will be used.