Effectiveness of Seasonal Malaria Chemoprevention in Koulikoro, Mali
The objectives of this project are:
- To determine the effectiveness of SMC extended to children up to 10 years old on the incidence and prevalence of malaria over entire district of Koulikoro using a cluster randomized controlled trial study design
- To assess potential long term effect of SMC on malaria epidemiology (acquisition of protective immunity, parasite population dynamics, drug resistance and transmission)
- To conduct a cost-effectiveness analysis of SMC extended to 5-10 years old as compared with standard protocol of SMC provision to children less than 5 years old with regard to delivery and implementation strategies and financial cost per malaria case averted and per child
The findings from years 1 and 2 implementation studies will serve as the go (conduct high quality efficacy study) versus no-go (conduct further intervention effectiveness studies around operations and implementation strategies) criteria for years 3-5.
ClinicalTrials.gov Identifier: NCT04149106
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||4556 participants|
|Intervention Model:||Crossover Assignment|
|Intervention Model Description:||
A cluster randomized design will be used.