Last Updated

17 Dec 2019

Effectiveness of Seasonal Malaria Chemoprevention in Koulikoro, Mali

Objectives

The objectives of this project are:

  1. To determine the effectiveness of SMC extended to children up to 10 years old on the incidence and prevalence of malaria over entire district of Koulikoro using a cluster randomized controlled trial study design
  2. To assess potential long term effect of SMC on malaria epidemiology (acquisition of protective immunity, parasite population dynamics, drug resistance and transmission)
  3. To conduct a cost-effectiveness analysis of SMC extended to 5-10 years old as compared with standard protocol of SMC provision to children less than 5 years old with regard to delivery and implementation strategies and financial cost per malaria case averted and per child 
Principal Investigator
Rationale and Abstract

The findings from years 1 and 2 implementation studies will serve as the go (conduct high quality efficacy study) versus no-go (conduct further intervention effectiveness studies around operations and implementation strategies) criteria for years 3-5.

ClinicalTrials.gov Identifier: NCT04149106

Study Design
Study Type  : Interventional  (Clinical Trial)
Estimated Enrollment  : 4556 participants
Allocation: Randomized
Intervention Model: Crossover Assignment
Intervention Model Description:

A cluster randomized design will be used.

Date

2019 Apr - 2020 Mar

Total Project Funding

$458,810

Funding Details

3U19AI129387-03S1, subproject 8667. Budget end date March 2020.
Project Site