Last Updated

27 Nov 2020

A controlled, parallel, cluster-randomized trial of community-wide screening and treatment of asymptomatic carriers of Plasmodium falciparum in Burkina Faso


The general aim is to evaluate the impact of systematic detection by rapid diagnostic test (RDT) and treatment of asymptomatic carriers of P. falciparum on disease transmission and susceptibility to clinical malaria episodes. 

Principal Institution(s)

Rationale and Abstract

Outcome measures:
- Incidence of symptomatic malaria episodes with a parasite density >5,000/μL 
- Change in hemoglobin levels (g/dL) in asymptomatic carriers
- Prevalence of gametocyte carriers
- Change in malaria transmission as measured by entomological inoculation rate

Study Design

Study Type: Interventional (Clinical Trial)
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Enrollment: 14075 participants

Eighteen villages were randomized (1:1) to study arms and inhabitants participated in four community screening campaigns: three before the rainy season ~1 month apart, and the fourth after the rains at ~12 months.