Last Updated

17 Jun 2019

Applying molecular epidemiology to accelerate to zero

Objectives

By using genetic fingerprints of parasites, to create networks of biological transmission links between infected individuals in order to estimate:

  • Classification of malaria cases as imported or local
  • Measurement of local transmission (Rc)
  • Measurement of parasite flow between one geographic region and another
  • Identification of putative risk groups responsible for sustaining transmission (hotpops)
  • Evidence of cross-border connectivity of parasite populations using genetic data and travel history
Principal Investigator
Rationale and Abstract

Genotyping: 26 microsatellites (all) + whole genome sequencing and targeted next-generation sequencing on a subset
CDR Data: the nightly location for all subscribers was estimated based on their most used tower. Health facility catchments were assigned the nearest mobile phone tower.
Travel survey data: Individuals reported the number of nights spent at other local and international locations. 92% did not report travel. 

Date

2015 Jul - 2018 Mar