Last Updated

19 Feb 2019

Ivermectin development roadmap

Objectives

The overall goal of this project is to design a roadmap leading to the use of ivermectin as a public health intervention for complementary malaria vector control in endemic areas.

Principal Investigator
Rationale and Abstract

As malaria transmission is curbed by effective vector control with indoor tools (LLINs and IRS), drug-based strategies and economic development, the relative importance of residual transmission increases. This poses a serious threat to reaching elimination goals.

Mass administration of ivermectin (a drug capable of targeting malaria vectors regardless of time and place of biting) has gained increased attention by funders, academia and international organizations as a potential complementary tool for malaria elimination. There is now clear WHO guidance on the Preferred Product Characteristics for such a tool and a draft Target Candidate Profile by Medicines for Malaria Venture.  Still, the malaria community lacks alignment on the processes needed to transform the potential of ivermectin into an implemented tool. This project aims to produce a roadmap for such transformation including key issues to be resolved (dose, regimen, eligibility, regulatory pathway), go/no-go criteria along the evaluation and development process. For this, the ivermectin taskforce, a group of experts and stakeholders, will work on complementary streams to produce a roadmap document and accompanying TPPs that can guide related investments and efforts.

Date

2017 Aug - 2018 Aug

Total Project Funding

$99,985

Funding Details

Project Site