Genomic epidemiology of Plasmodium falciparum in the context of mass drug administration for malaria control on the Bijagos Archipelago of Guinea Bissau
The main objective will be to investigate the population structure and drug resistance profile of P. falciparum before a mass drug administration (MDA) intervention, the impact of MDA on P. falciparum transmission and the characterisation and tracking of residual P. falciparum variants during and post-MDA using novel molecular and modelling techniques.
This project is nested within a currently funded cluster (island) randomised placebo-controlled trial on the Bijagos Archipelago of Guinea-Bissau, aimed at evaluating the added impact of mass drug administration (MDA) with adjunctive ivermectin in addition to the ACT dihydroartemisinin-piperaquine.
Molecular and bioinformatics techniques will be used to determine parasite transmission, population structure and resistance profile to known anti-malarial drugs at baseline using field collected dry blood spots. P. falciparum whole genome sequencing and multiplex PCR approaches to genotyping will be used to characterise and track P. falciparum variants before and after MDA in combination with field-based metadata on human population movement during the study.